HOW ANTISENSE WORKS
Antisense oligonucleotides function by hybridizing to their target mRNA; thereby, blocking translation. Translation is inhibited by either degradation of the transcript by RNase H at the RNA:DNA duplex, or by blocking the ribosome thus subsequently inhibiting protein synthesis.
BENEFITS OF ANTISENSE OLIGONUCLEOTIDES
Sequence specific inhibition of gene expression
Requires only partial gene sequences, including ESTs
Faster and cheaper than transgenic experiments
Better experimental control and success than with antisense expression vectors
Cost effective technology for drug discovery and target validation
ANTISENSE APPLICATIONS
In Vitro
Antisense can easily be used in cell culture making it a cost effective knock out technology.
In Vivo
Tissue specific injection/Microinjection
I.V.
Inhalation
Trans-dermal absorption
Ophthalmically
Orally
Olfactory
moleculA is focused on gene expression solutions using proprietary antisense technology and other innovative approaches. Using our proprietary A.I.M.™ (Antisense Integratted Mapping) technology, Molecula consistently delivers active antisense oligonucleotides for gene suppression and target validation studies.
