NEW! Molecula antisense design citations
Molecula is focused on gene expression solutions using proprietary antisense technology and other innovative approaches. Using our proprietary A.I.M.™ (Antisense Integratted Mapping) technology, Molecula consistently delivers active antisense oligonucleotides for gene suppression and target validation studies.
2004
Koulu M, Movafagh S, Tuohimaa J, Jaakkola U, Kallio J, Pesonen U, Geng Y, Karvonen MK, Vainio-Jylha E, Pollonen M, Kaipio-Salmi K, Seppala H, Lee EW, Higgins RD, Zukowska Z. Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization Ann Med. 2004;36(3):232-40
2003
Oh H, Wang SC, Prahash A, Sano M, Moravec CS, Taffet GE, Michael LH, Youker KA, Entman ML, Schneider MD. Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5378-83. [abstract]
Li S, Dai Y, Quock RM. Antisense knockdown of neuronal nitric oxide synthase antagonizes nitrous oxide-induced behavior. Brain Res. 2003 Apr 4;968(1):167-70.
Ryu H, Lee J, Olofsson BA, Mwidau A, Deodeoglu A, Escudero M, Flemington E, Azizkhan-Clifford J, Ferrante RJ, Ratan RR. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4281-6. Epub 2003 Mar 14 [abstract]
Sano M, Schneider MD Cyclins that don't cycle:-cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size. Cell Cycle. 2003 Mar-Apr;2(2):99-104.[abstract]
Qing X, Keith IM. Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L86-96. Epub 2003 Mar 07. [abstract]
Ramana KV, Friedrich B, Bhatnagar A, Srivastava SK Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells.
FASEB J. 2003 Feb;17(2):315-7. Epub 2002 Dec 17. [abstract]
2002
Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, Michael LH, DeMayo FJ, Schneider MD. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med. 2002 Nov;8(11):1310-7. [abstract]
Ramana KV, Chandra D, Srivastava S, Bhatnagar A, Aggarwal BB, Srivastava SK.
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells.
J Biol Chem. 2002 Aug 30;277(35):32063-70. [abstract]
Patent Applications Using moleculA Designs:
Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy [abstract]
Suppression of eIF5A1 expression to prevent retinal ganglion cell death
